Unit 51, also referred to as Big Creek is located on the southern border of the state, southeast of Encampment. Made up of high plain desert and part of the Medicine Bow Mountain Range, this area a lot of BLM and state land, as well as a good portion within the Medicine Bow-Routt National Forests. A large majority of the public lands found in this unit will not hold any notable populations of antelope which can greatly concentrate hunting pressure in public areas where antelope are present.

Decent public access is found here but hunting pressure can be high at times. Private lands will generally hold the best odds of success as well as the biggest bucks.