Hunters considering Unit S22 in Colorado highlight its challenging terrain, emphasizing the necessity of being in excellent physical condition, as one hunter's experience with llamas and significant weight loss suggests. The unit offers diverse big game sightings, appealing to those with high preference points, such as those with 14 to 17 points considering it for sheep and mule deer. Reaching out to local resources like Western Big Game Scouting is recommended, as it has successfully helped hunters in the past. Engaging with experienced hunters and leveraging scouting services can considerably enhance preparation and success in this demanding unit.