Hunters discussing Wyoming's Area 106 highlight its challenging terrain and abundant wildlife, including mule deer, elk, and a significant grizzly bear presence. Many describe it as a migratory unit with deer residing at higher elevations, mainly above 8800 feet, making the hunt quite demanding, especially for solo hunters due to the density of grizzlies and difficult access roads. It's noted that planning for late-season hunting, potentially after significant snowfall, can increase the chances of encountering mature mule deer as they migrate out of Yellowstone. Hunters are advised to be well-prepared for backcountry conditions, aware of the strict hunting tag regulations and points accumulation system, and consider hunting with a partner for both safety and enhanced experience.